Antidepressants really do work, and should be taken by millions more people, claimed newspaper headlines last week. The reality is more nuanced. The positive press was triggered by a study that found these medicines do have a small benefit contradicting previous claims of ineffectiveness. The work, by a respected group of researchers, reviewed over 500 trials of 21 different drugs, involving more than 100,000 people with depression. Media reports say the new findings should put the controversy to bed. Let's not be too hasty. Previous studies found that antidepressants don't work in people with mild-to-moderate depression. Most of the people in the review had more severe depression. So it is good news for that group, but it doesn't resolve the controversy
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