A pro-metastatic tRNA pathway

• Autores: Canan Kuscu, Anindya Dutta
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 6, 2016, págs. 1314-1315
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • tRNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of pro-metastatic proteins.