Resumen de Dangerous entrapment for NRF2

Vera Gorbunova, Sarallah Rezazadeh, Andrei Seluanov

• Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.