Síndrome de Stevens Johnson: necrólisis Epidérmica Tóxica de etiología multifactorial

• Autores: Carlos Tablante, Gabriela Madrid, Ernesto Madrid, Caren González, Carmen C. Solorzano, Claudy Blanco
• Localización: Vitae: Academia Biomédica Digital, ISSN-e 1317-987X, Nº. 26 (Enero-Marzo), 2006
• Idioma: español
• Texto completo no disponible (Saber más ...)
• Resumen

  • Stevens Johnson Syndrome (SJS) has been defined as a multiform erythema vesiculobullous of the skin and other organs. It's considered as an initial stage of a dermal reaction in which the most severe form of presentation is Toxic Epidermal Necrolysis (TEN).This is an acute systemic inflammatory disease that involves more than 30 % of epidermal detachment of the body surface. Etiologically it's related to the use of some drugs in 60% of the cases, besides herpes simplex, mycoplasma infection and some genetics factors. SJS has a sudden onset and can be preceded for a prodromous of malaise between 1-14 days. The most important clinical finding is a target erythematous and papular lesion that spreads centripetally evolving into a central vesicle. Generally involves mucous membrane often oral, conjunctival and genital areas. SSJ occasionally can develop a TEN characterized by painful necrotic cutaneous lesions epidermal loss and bullous lesions spreading to an extensive skin detachment compromising vital functions producing electrolyte inbalance , renal and ocular impairment, excessive energy expenditure and potential sepsis risk. In this study we report a nine year old female with diagnose of Viral Meningoencephalitis by Cytomegalovirus. In the fourteenth day of hospitalization develops a SJS/TEN with satisfactory clinical output. Emphasizing the multifactorial etiology of this disease where drugs and infectious cause acts as a synergic combine bringing the complexity of the case.