Room-Temperature C–H Functionalization Sequence under Benchtop Conditions for the Undergraduate Chemistry Laboratory

• Shuming Chen ^[1]
  1. [1] University of California, United States
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 95, Nº 6, 2018, págs. 1050-1053
• Idioma: inglés
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• Resumen

  • An iridium(III)-mediated C–H functionalization sequence involving a concerted cyclometalation–deprotonation/migratory insertion pathway is reported for the undergraduate chemistry laboratory. The air- and water-stable iridacycle intermediates are readily isolated and characterized by NMR spectroscopy. Both steps of the experiment are performed at room temperature under benchtop conditions, rendering the protocol suitable for a wide range of student skill levels.