Ozone therapy immunomodulatory effect in the selective immunoglobulin A deficiency.

• Autores: Jacqueline Diaz Luis, Silvia Menéndez Cepero, Consuelo Macías
• Localización: Journal of Ozone Therapy (JO3T), ISSN-e 2444-9865, Vol. 1, Nº. 1, 2015, págs. 5-5
• Idioma: inglés
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• Resumen

  • The aim of this work is to study the ozone therapy effect in the selective immunoglobulin A deficiency. Taking into account that ozone is able to stimulate several biological systems, to modulate cytokines levels and to enhance immunoglobulin production, a phase II, controlled and randomized, clinical trial was performed. Forty patients were divided at random into 2 groups of 20 patients each: Ozone – received 42 sessions by rectal insufflations during three months, using scaling doses. Control – received subcutaneous Hebertrans during three months. Patients were evaluated at the beginning and one and six months later. The IgA improved, with significant difference (p=0.04) between both groups. The blood levels of IgG were increased significantly (p=0.03) in the group treated with ozone compared to the control group. Leukocyte activity improved significantly (p=0.04) one month later, achieving 97 % of normal values. The clinical evolution was satisfactory in 87 and 80 % of the children that received ozone and Hebertrans, respectively without side effects reported.