Experience like bullying make the blood-brain barrier leaky, leading to brain inflammation and leaving people vulnerable to depression, according to studies of human brains and mice. Anything that threatens their sense of worth is a type of social stress--be it bullying, body-image issues, social anxiety or extreme shyness. To see how such stresses affect mood, Scott Russo of the Icahn School of Medicine at Mount Sinai, New York, and his team exposed 24 small, subordinate mice to larger, dominant mice for 10 minutes every day, for 10 days. Ten of the mice coped well, but 14 became socially withdrawn and more timid.
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