Sorting out presenilins in alzheimer’s disease

• Autores: Michael S. Wolfe, Bruce A. Yankne
• Localización: Cell, ISSN 0092-8674, Vol. 166, Nº. 1, 2016, págs. 13-15
• Idioma: inglés
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• Resumen

  • Mutations in the presenilins that cause familial Alzheimer’s disease alter the activity of these proteases to increase generation of an aggregation-prone isoform of the amyloid β-peptide (Aβ). How these mutations do so has been unclear. Sannerud et al. now show that regulation of subcellular localization plays a central role, advancing our understanding of the cell biology of Alzheimer’s disease.