Mitochondrial networking in T cell memory

• Autores: Marc Liesa, Orian S Shirihai
• Localización: Cell, ISSN 0092-8674, Vol. 166, Nº. 1, 2016, págs. 9-10
• Idioma: inglés
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• Resumen

  • T-lymphocytes show large changes in ATP demand and nutrient utilization, imposed by their different roles as T memory and T effector cells. Therefore, T cell remodeling represents a bioenergetic challenge to mitochondria. New work from Buck et al. links changes in mitochondrial shape to T cell fate choice.