Resumen de Medical Therapy for Cushing’s Syndrome in the Twenty-first Century

Nicholas A. Tritos, Beverly M.K. Biller

• rompt control of hypercortisolism is needed to reverse clinical and biochemical man- ifestations and decrease excess morbidity and mortality in patients with endogenous Cushing’s syndrome (CS).

  Resection of the underlying tumor is currently the mainstay of treatment of CS.

  After trans-sphenoidal pituitary surgery, persistent or recur- rent hypercortisolism may occur in, respectively, 10% to 20% and 20% to 30% of patients with pituitary corticotroph adenomas (ie, Cushing’s disease [CD]), which