Recent Advances on Subclinical Hypercortisolism

• Autores: Guido Zavatta
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 47, Nº. 2, 2018 (Ejemplar dedicado a: Cushing's Syndrome), págs. 375-383
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The term “adrenal incidentaloma” refers to an adrenal mass discovered during im- aging performed for reasons unrelated to adrenal disorders. Even though most adrenal incidentalomas do not show biochemical evidence of hormonal excess, up to 30% of those tumors are associated with subclinical hypercortisolism (SH).

    SH is a pathologic condition defined as biochemical evidence of hypercor- tisolism in patients without typical sign s or symptoms of Cushing’s syndrome.

    In recent years, this condition has been evaluated in several studies that increased the understanding regarding its natural history and the outcomes of available therapeutic options. The refined radiological techniques and the introduction of metabolomic profiling by mass spectrome try have improved the performance of current diagnostic criteria and provided new insights regarding the pathogenesis of subtle cortisol excess. The purpose of this review is to present the most recent advances in SH.