Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell

• Autores: Jitin Singla, Kyle M. McClary, Kate L. White
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 1, 2018, págs. 11-19
• Idioma: inglés
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• Resumen

  • The construction of a predictive model of an entire eukaryotic cell that describes its dynamic structure from atomic to cellular scales is a grand challenge at the intersection of biology, chemistry, physics, and computer science. Having such a model will open new dimensions in biological research and accelerate healthcare advancements. Developing the necessary experimental and modeling methods presents abundant opportunities for a community effort to realize this goal. Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic β–cell, a relevant target for understanding and modulating the pathogenesis of diabetes.