Resumen de Effects of S-adenosylmethionine on hepatic regeneration after partial hepatectomy in the rat

Valentín Pérez Pérez, Juan Manuel Corpa Arenas, M. Muñoz, L. Fernández, M. Abad, María Teresa Carbajo Rueda

• Effects of S-adenosylmethionine (SAME) on hepatic regeneration has been evaluated in hepatectomized rats. Reduced (GSH) or oxidized (GSSH) glutathione were determined and liver examined by histological methods. Liver weight, after hepatectomy, increased in SAME treated group that showed a decrease in the number of mitotic figures, suggesting some protective effect.. No changes in GSH were observed, possibly due to the short period of time elapse (48h) between the experimental procedures and GSH determination.