Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis

• Eudes-Freire Cardoso ^[2] ; Daniella-Reis-Barbosa Martelli ^[3] ; Renato-Assis Machado ^[1] ; Ricardo D. Coletta ^[1] ; Júlia-Duarte de Souza ^[4] ; Fernanda-Tófani Barbosa ^[2] ; Maria-Fernanda-Leite de Figueiredo ^[2] ; Luiz-Gonzaga-Vaz Coelho ^[4] ; Hercílio Martelli-Júnior ^[5]
  1. [1] Universidade Estadual de Campinas

     Universidade Estadual de Campinas

     Brasil

     
  2. [2] School of Medicine, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
  3. [3] School of Dentistry, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
  4. [4] Alfa Institute of Gastroenterology, Federal University of the State of Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil
  5. [5] School of Dentistry, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil; Center for the Rehabilitation of Craniofacial Anomalies, University of José do Rosário Vellano, Unifenas, Alfenas, Minas Gerais, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 23, Nº. 1 (January ), 2018
• Idioma: inglés
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• Resumen

  • To determine the frequency of nonsyndromic cleft lip and/or palate (NSCL/P) in first-degree relatives and to analyze the prevalence of tooth agenesis in patients with gastric cancer.

    This cross-sectional, observational, case-control study included 798 patients attended at hospital Santa Casa in Montes Claros, Minas Gerais and Alfa Institute of Gastroenterology of the Federal University of the Minas Gerais. Information on basic demographic data and tooth agenesis of both groups and their family history of NSCL/P in first-degree relatives were evaluated. The collected information was stored in a database and analyzed using statistical program SPSS® version 21.0 and the values with p<0.05 were considered statistically significant.

    Of the 798 patients, 113 (14.16%) consisted of the case group and 685 of the control group (85.84%). Non-Caucasian males were the most affected, although no differences among the groups were detected. Of all participants (n=798), 66 (8.27%) presented tooth agenesis and 25 (3.13%) presented oral cleft in first degree relative.

    Our results no found increase in the frequency of tooth agenesis in patients with gastric cancer and in the frequency of NSCL/P in the first-degree relatives of patients with gastric cancer.