Mechanisms of the evolutionary arms race between Vibrio cholerae and Vibriophage clinical isolates

• Autores: Minmin Yen, Andrew Camilli
• Localización: International microbiology: official journal of the Spanish Society for Microbiology, ISSN 1139-6709, Vol. 20, Nº. 3, 2017, págs. 116-120
• Idioma: inglés
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• Resumen

  • This review highlights recent findings on the evolutionary arms race between the causative agent of cholera Vibriocholerae and virulent bacteriophages (phages) ICP1, ICP2, and ICP3 isolated from cholera patient stool samples. We discussmechanisms of phage resistance such as a unique phage-inhibitory chromosomal island and mutations that affect phage receptorexpression. We also discuss the molecular characterization of ICP1 and its unique CRISPR-Cas system, which it uses to combatthe phage-inhibitory chromosomal island. The role of phages in the life cycle of V. cholerae has been increasingly recognized andinvestigated in the past decade. This article will review hypotheses as to how the predator-prey relationship may have an impacton infections within individuals and on the self-limiting nature of cholera epidemics. In addition, we put forth a strategy of usingphages as an intervention to reduce household transmission of cholera within a community.