Problemas clínicos en micología médica: problema número 51
- Autores: Mercedes Romero, Fernando Messina, Emmanuel Marin, Alicia Arechavala, Ricardo Negroni, Roxana Depardo, Laura Walker, Andrés Benchetrit, Gabriela Santiso
- Localización: Revista Iberoamericana de Micología, ISSN 1130-1406, Vol. 35, Nº. 1, 2018, págs. 56-58
- Idioma: español
- Títulos paralelos:
- Clinical problems in medical mycology: Problem number 51
- Enlaces
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Resumen
A 48 year-old immunocompetent woman, who had a nodular lesion in the neck and a dense infiltrate at the lower lobe of the left lung, presented at the Mycology Unit of Muñiz Hospital of Buenos Aires City. The pulmonary infiltrate disappeared spontaneously 3 months later. The histopathological study of the nodular lesion showed capsulated yeasts (mucicarmin and alcian blue positive stains) compatible with Cryptococcus. The mycological study of a new sample, obtained by a nodular puncture, allowed the isolation of yeasts, identified as Cryptococcus gattii (VGII). Latex test for Cryptococcus capsular antigen in serum was positive (1/100). CSF cultures rendered negative results. Fluconazole at a daily dose of 800mg was given during 45 days with partial improvement; as cultures from a new clinical sample were positive for Cryptococcus, the antimycotic was changed to itraconazole 400mg/day for 5 months, with an excellent clinical response
