Antibiotic Killing through Incomplete DNA Repair

• Autores: Benno H. Ter Kuile, Marloes Hoeksema
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 26, Nº. 1, 2018, págs. 2-4
• Idioma: inglés
• Enlaces
  • Texto Completo Ejemplar
• Resumen

  • Two recent studies show that incomplete repair of DNA damage due to oxidized nucleotides is crucial for reactive oxygen species (ROS)-related antimicrobial lethality. Using widely different experimental approaches they both reach the same conclusions on the role of downstream ROS production in cell killing upon exposure to bactericidal antimicrobials.