Chemokine-Mediated Choreography of Thymocyte Development and Selection
- Autores: Jessica N. Lancaster, Yu Li , Lauren R. Ehrlich
- Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 2, 2018, págs. 86-98
- Idioma: inglés
- Enlaces
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Resumen
As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is enforced by the ordered expression of chemokine receptors. Herein, we provide an updated perspective on T cell differentiation through the lens of recent advances that illuminate the dynamics of chemokine-driven thymocyte migration, localization, and interactions with stromal cells. We consider these findings in the context of earlier groundwork exploring the contribution of chemokines to T cell development, recent advances regarding the specificity of chemokine signaling, and novel techniques for evaluating the T cell repertoire. We suggest future research should amalgamate visualization of localized cellular interactions with downstream molecular signals.
