Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma
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M.A.S. Malaquias [1] ; L.A. Oyama [1] ; P.C. Jericó [1] ; I. Costa [2] ; G.Padilha [2] ; S.Nagashima [1] ; M.Lopes-Pacheco [2] ; C.L.K.Rebelatto [1] ; P.V.Michelotto [1] ; D.G.Xisto [2] ; P.R.S.Brofman [1] ; P.R.M.Rocco [2] ; L. de Noronha [1]
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[1] Pontifícia Universidade Católica do Paraná
Pontifícia Universidade Católica do Paraná
Brasil
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[2] Universidade Federal do Rio de Janeiro
Universidade Federal do Rio de Janeiro
Brasil
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 46, Nº. 2, 2018, págs. 136-143
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Asthma is a heterogeneous disease characterised by chronic airway inflammation. One of the most devastating consequences of this inflammatory process is the generation of reactive oxygen and nitrogen species responsible for oxidative stress. The aim of this study is to analyse the efficiency of treatment with human bone marrow-derived mesenchymal stromal cells (hMSC) in maintaining the oxidative balance in a murine model of allergic asthma by quantifying nitrotyrosine in lung tissues. After confirmation of asthma in the experimental model, samples of lung parenchyma were submitted to immunohistochemical assessment. Intravenous administration of hMSC reduced the levels of nitrotyrosine in the ASTHMA-hMSC group compared to those in the ASTHMA-SAL group. In conclusion, therapeutic administration of hMSC had a beneficial effect on oxidative stress, reducing the levels of nitrotyrosine in lung tissues in a model of allergic asthma.
