Determination of the Acid Dissociation Constant of a Phenolic Acid by High Performance Liquid Chromatography: An Experiment for the Upper Level Analytical Chemistry laboratory

• Ghada Rabah ^[1]
  1. [1] North Carolina State University

     North Carolina State University

     Township of Raleigh, Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 95, Nº 2, 2018, págs. 310-314
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A high performance liquid chromatography (HPLC) experiment for the upper level analytical chemistry laboratory is described. The students consider the effect of mobile-phase composition and pH on the retention times of ionizable compounds in order to determine the acid dissociation constant, Ka, of a phenolic acid. Results are analyzed using nonlinear regression.