Tuning biased GPCR signaling for physiological gain

• Autores: Skylar Spangler, Michael R. Bruchas
• Localización: Cell, ISSN 0092-8674, Vol. 171, Nº. 5, 2017, págs. 989-991
• Idioma: inglés
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• Resumen

  • Effective and safe doses of opiate painkillers, like morphine, can be limited by respiratory depression. Schmid et al. (2017) now present a quantitative method to design ligands and correlate GPCR signaling bias to the dose separation between therapeutic and adverse effects in animals.