Characteristics of the cornea and the ocular surface in a population of patients with congenital aniridia

• Autores: Kelma Macedo, Maria Fideliz de la Paz Dalisay, Juan Pedro Álvarez de Toledo Elizalde, Francesc Tresserra Casas, Juan José Pérez Santonja, Laura De Benito Llopis, Jose María Panades, Ralph Michael, Zorella Blanco
• Localización: Journal of Emmetropia: Journal of Cataract, Refractive and Corneal Surgery, ISSN-e 2171-4703, Vol. 3, Nº. 3, 2012, págs. 130-139
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • PURPOSE: To describe corneal and ocular surface abnormalities in patients with congenital aniridia.

    METHODS: We examined 50 eyes in 25 patients with congenital aniridia. Schirmer’s test I and II, tear film break-up time, vital staining, tear ferning pattern test and impression cytology, Cochet-Bonnet aesthesiometry, specular microscopy and ultrasonic pachymetry were carried out.

    RESULTS: Based on Mackman’s classification, we found grade 0 in 12%, grade 1A in 52%, grade 1B in 20%, and grade 2 in 16% cases. Age, history of ocular surgery, dry eye score and aesthesiometry correlated with the degree of aniridia-related keratopathy (ARK).

    Schirmer’s test I was normal in 86.8%, Schirmer’s test II in 94.4% of the eyes and TFBUT in 83.3% of the cases. Corneal staining was altered in 54.2%, and conjunctival staining was altered in 45.7%. The tear ferning pattern was abnormal in 80%. Conjunctival metaplasia was present in 76.9%, and the presence of conjunctival goblet cells on the cornea correlated weakly with the degree of ARK. Corneal endothelial cell density was normal in 13 eyes of 9 patients (2190.84 cells/mm2 ). Ultrasonic pachymetry was higher than average in all eyes examined (587 microns).

    CONCLUSION: Simple corneal and ocular surface tests are useful in assessing the presence and degree of aniridia-related keratopathy. Impression cytology is a useful tool in diagnosing metaplasia and limbal stem-cell deficiency in patients with congenital aniridia. CochetBonnet aesthesiometry results and tear ferning patterns are reported for the first time in patients with congenital aniridia