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Use of Cell-Free Fetal DNA in Maternal Plasma for Noninvasive Prenatal Screening

  • Autores: Amy J. Wagner, Michael E. Mitchell, Aoy Tomita-Mitchell
  • Localización: Clinics in Perinatology, ISSN 0095-5108, Vol. 41, Nº. 4, 2014, págs. 957-966
  • Idioma: inglés
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  • Resumen
    • Noninvasive prenatal testing (NIPT) using cell-free fetal (cfDNA) offers potential as a screening tool for fetal anomalies. All pregnant women should be offered prenatal screening and diagnostic testing based on current guidelines. Adoption of NIPT in high-risk pregnancies suggests a change in the standard of care for genetic screening; there are advantages to an accurate test with results available early in pregnancy. This accuracy decreases the overall number of invasive tests needed for diagnosis, subjecting fewer pregnancies to the risks of invasive procedures. Women undergoing NIPT need informed consent before testing and accurate, sensitive counseling after results are available.


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