Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

• Autores: Koji Atarashi, Wataru Suda, Chengwei Luo
• Localización: Science, ISSN 0036-8075, Vol. 358, Nº 6361, 2017, págs. 359-365
• Idioma: inglés
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• Resumen

  • Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.