Olanzapine Linked With Potentially Fatal Skin Reaction

• Autores: Rebecca Voelker
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 23, 2016, pág. 2514
• Idioma: inglés
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• Resumen

  • Nearly 2 dozen cases of a rare but serious skin reaction linked over the past 20 years with the antipsychotic medication olanzapine have prompted a warning from the FDA.

    The agency will add information to drug labels for all olanzapine-containing products warning that they may cause drug reaction with eosinophilia and systemic symptoms (DRESS), which can start as a rash that sometimes spreads across the entire body. Fever, swollen lymph nodes, and a swollen face may accompany the rash. The condition results in a higher-than-normal number of eosinophils that can cause inflammation or swelling. In severe cases, damage to organs including the liver, kidneys, lungs, heart, or pancreas may occur.