Diet and Exercise for Obese Patients With Heart Failure

• Autores: Dimitrios Farmakis, John Parissis, Gerasinos S. Filippatos, Dalane W. Kitzman, Mark J. Haykowsky
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 23, 2016, págs. 2618-2620
• Idioma: inglés
• Títulos paralelos:
  • Diet and Exercise for Obese Patients With Heart Failure—Reply
• Texto completo no disponible (Saber más ...)
• Resumen
  • English

    The study by Dr Kitzman and colleagues documented a beneficial effect of diet and physical training on exercise capacity in obese older patients with heart failure with preserved ejection fraction (HFPEF).1 The study is among the few reporting encouraging results in this population. We have also observed an improvement in exercise capacity and quality of life by applying functional electrical stimulation of peripheral muscles as an alternative form of exercise in patients with HFPEF

  • English

    The elegant study by Dr Farmakis and colleagues of electrical stimulation provided the most definitive evidence that skeletal muscle abnormalities are important contributors to severe exercise intolerance, which is the primary manifestation of chronic HFPEF, and suggested that skeletal muscle abnormalities are promising therapeutic targets. This was a key premise of our trial.

    In addition to meeting 2 sets of diagnostic criteria commonly used in heart failure studies, all our patients also met both the current US1 and European HFPEF criteria. Ninety-six percent of patients had abnormal diastolic filling patterns, mean e′ was moderately reduced (6.2 cm/s), and E/e′ was significantly increased (mean, 13.2). Most had left ventricular hypertrophy by echocardiography.