PD-1hiCXCR5−CD4+ TFH Cells Play Defense in Cancer and Offense in Arthritis

• Autores: Chunyan Gu-- Trantien, Karen Willard Gallo
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 12, 2017, págs. 875-878
• Idioma: inglés
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• Resumen

  • T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5−CD4+ T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells?