Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient

• Autores: Alejandro Jiménez Sánchez, Danish Memon, Stephane Pourpe, Harini Veeraraghavan
• Localización: Cell, ISSN 0092-8674, Vol. 170, Nº. 5, 2017, págs. 927-938
• Idioma: inglés
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• Resumen

  • We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8+ and CD4+ T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8+ T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy.