Resumen de Reprogramming enhancers to drive metastasis

Raul Mostoslavsky, Nabel Bardeesy

• Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.