The tropism of pleiotrophin: Orchestrating glioma brain invasion

• Autores: David. H. Gutmann
• Localización: Cell, ISSN 0092-8674, Vol. 170, Nº. 5, 2017, págs. 821-822
• Idioma: inglés
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• Resumen

  • The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.