How Depressed Mood May Develop After Viral Infection

• Autores: Tracy Hampton
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 21, 2016, pág. 2267
• Idioma: inglés
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• Resumen

  • New research reveals that viral infections can trigger brain endothelial and epithelial cells to produce a cytokine that impairs neuronal firing in the hippocampus, leading to depressive-like behavior and cognitive impairments (Blank T et al. Immunity. doi:10.1016/j.immuni.2016.04.005 [published online April 19, 2016]).

    After infecting mice with the vesicular stomatitis virus, which causes flu-like symptoms in humans, investigators at the University of Freiburg in Germany assessed the animals’ behavior in a forced swim test. Viral infection increased the duration of animals’ immobility response, an indicator of depressive-like behavior.