The Potential for Postrandomization Confounding in Randomized Clinical Trials

• Autores: JoAnn E. Manson, Chrisandra L. Shufelt, James M. Robins
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 21, 2016, págs. 2273-2274
• Idioma: inglés
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• Resumen

  • In this Viewpoint, JoAnn Manson and colleagues discuss the risk of postrandomization “confounding,” a bias that can be introduced in long-duration trials of sustained interventions, using statin initiation after randomization in Women’s Health Initiative trials as an example.