Circulating Normal IgG as Stimulator of Regulatory T Cells: Lessons from Intravenous Immunoglobulin

• Autores: Mohan S. Maddur , Srini V. Kaveri, Jagadeesh Bayry
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 38, Nº. 11, 2017, págs. 789-792
• Idioma: inglés
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• Resumen

  • Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors’ plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activation and expansion of regulatory T (Treg) cells by multiple mechanisms via antigen-presenting cells (APCs).