Transcription-replication conflicts: orientation matters

• Autores: Yea-Lih Lin, Philippe Pasero
• Localización: Cell, ISSN 0092-8674, Vol. 170, Nº. 4, 2017, págs. 603-604
• Idioma: inglés
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• Resumen

  • Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in bacteria and in human cells by promoting the formation of RNA-DNA hybrids known as R-loops.