The role of microRNAs in oral lichenoid disorders. Systematic review

• Amaia Setién-Olarra ^[1] ; María-Luisa Gainza-Cirauqui ^[2] ; José-Manuel Aguirre-Urizar ^[1] ; Xabier Marichalar-Mendia ^[1]
  1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Leioa, España

     
  2. [2] University of Malta

     University of Malta

     Malta

     
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 22, Nº. 5, 2017
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Certain changes in the microRNA expression are considered to be associated with chronic inflammatory processes and with the malignant transformation of oral potentially malignant disorders. The purpose of this systematic review is to update the existing data on the aberrant microRNA expression profiles identified in oral lichenoid disease (OLD).

    A search in PubMed-Medline and Scopus was performed on the English literature published between 2010 and August 2016 using the following keywords: oral lichenoid disease, oral lichen planus and microRNA.

    Originally, 25 articles were considered, of which 12 case-control articles were selected according to the inclusion/exclusion criteria.

    OLD seems to have altered microRNA expression profile. Certain altered microRNAs (146a, 155) may be useful as biomarkers for this disorder. More studies including larger number of cases are needed in order to study further on the biological processes and on the regulation pathways of these altered microRNAs.