Type of surgical treatment and recurrence of oral leukoplakia: a retrospective clinical study

• Luís Monteiro ^[2] ; Cinzia Barbieri ^[1] ; Saman Warnakulasuriya ^[3] ; Marco Martins ^[4] ; Filomena Salazar ^[5] ; José-Júlio Pacheco ^[5] ; Paolo Vescovi ^[1] ; Marco Meleti ^[1]
  1. [1] University of Parma

     University of Parma

     Parma, Italia

     
  2. [2] Medicine and Oral Surgery Department, Cancer Research Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), University Institute of Health Sciences (IUCS), CESPU, Portugal; Stomatology and Dental Medicine Department, Valongo Nossa Senhora da Conceição Hospital, Portugal
  3. [3] Oral Medicine, King’s College London, the WHO Collaborating Centre for Oral Cancer, London, United Kingdom
  4. [4] Stomatology and Dental Medicine Department, Valongo Nossa Senhora da Conceição Hospital, Portugal
  5. [5] Medicine and Oral Surgery Department, Cancer Research Group, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), University Institute of Health Sciences (IUCS), CESPU, Portugal

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 22, Nº. 5, 2017
• Idioma: inglés
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• Resumen

  • Oral leukoplakia (OL) is the most typical potentially malignant disorder of the oral mucosa. We aimed to evaluate the clinical outcome of oral leukoplakia treated with several types of lasers and with the use of quantic molecular resonance (QMR) lancet, in terms of recurrence rate.

    Eighty-seven previously untreated OL (52 occurring in females and 35 in males, mean age of 59.4 ± 13.9 years) were consecutively submitted to surgical treatment at University Hospital of Parma, Italy, and Hospital de Valongo, Portugal, (1999 to 2012). Interventions were subclassified into 5 groups according to the instrument used for the surgical removal of OL (cold blade – 17; Nd:YAG 1064nm laser – 14; Er:YAG 2940nm laser - 33; CO2 10600nm laser – 15; and QMR scalpel – 8). The mean follow-up period after treatment was 21.6 months (range 1-151 months). The outcome of treatment was scored through the same clinical protocol in the two participating units. Statistical analysis were carried by univariate analysis using chi-square test (or Pearson´s test when appropriate).

    Recurrences were observed in 24 cases of OL (27.6%). Malignant transformation occurred in one patient (1.1%) after a period of 35 months. Statistical comparison of the 5 surgical treatment modalities showed no differences in clinical outcomes nor in the recurrence rate of OL. However, when Er:YAG laser group was compared with traditional scalpel, a significantly better outcome in cases treated with Er:YAG laser (P = 0.015) was highlighted.

    Our results suggests that Er:YAG laser could be a promising option for the treatment of OL.