Comparison of cardiac output measured by use of computed tomography and thermodilution in dogs

• Autores: Sharon Tenenbaum, Fernando L. Garcia Pereira, Clifford R. Berry., Tori Obert
• Localización: American Journal of Veterinary Research, ISSN-e 1943-5681, ISSN 0002-9645, Vol. 78, Nº. 8, 2017, págs. 906-909
• Idioma: inglés
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• Resumen

  • OBJECTIVE To compare cardiac output (CO) measured by use of CT coronary angiography and thermodilution (criterion-referenced standard) at various CO values, record adverse effects, and determine the time needed to measure CO.

    ANIMALS 5 healthy purpose-bred Beagles (2 males and 3 females).

    PROCEDURES A prospective nonrandomized crossover study was conducted. Dogs were premedicated with butorphanol tartrate (0.2 mg•kg−1, IM). Anesthesia was induced by IV administration of etomidate (1 to 2 mg•kg−1) and midazolam (0.25 mg•kg−1). Orotracheal intubation was performed, and anesthesia was maintained by administration of isoflurane. The CO was determined by use of thermodilution and by use of CT at 3 CO values. Dobutamine was infused at various rates to obtain the 3 CO values.

    RESULTS 13 values were obtained and analyzed. The mean ± SD difference between methods was 0.09 ± 0.71 L•min−1 (95% confidence interval [CI], 0.52 to −0.34 L•min−1). Only 1 of 13 values was located on the 100% agreement line (ie, 0 line), 7 of 13 values were located within the 95% CI, and 5 of 13 values were outside the 95% CI.

    CONCLUSIONS AND CLINICAL RELEVANCE For this study, there was poor agreement between the 2 methods. The 95% CI interval was 0.52 to −0.34 L•min−1, and 5 of 13 values were outside the 95% CI. Therefore, results for the CT method appeared to be inappropriate for use in making clinical decisions.