A randomised controlled trial to investigate the remineralising potential of Tooth Mousse™ in orthodontic patients

• Autores: Andrew P. Garry, Norah L. Flannigan, Lee Cooper, Girvan Burnside Gleb Komarov, Sue M. Higham
• Localización: Journal of orthodontics, ISSN-e 0301-228X, ISSN 1465-3125, Vol. 44, Nº. 3, 2017, págs. 147-156
• Idioma: inglés
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• Resumen

  • Objective:To investigate the remineralisation of enamel subsurface lesions treated with fluoridetoothpaste (1450 ppm) or a combination of fluoride toothpaste in addition to Tooth Mousse™.Design:Anin situ, cross-over, randomised controlled trial.Setting:Orthodontic department at Liverpool University Dental Hospital, UK. Participants: Twelvepatients receiving fixed orthodontic treatment. Methods: Demineralised subsurface enamellesions were placed in a carrier and attached onto a fixed orthodontic appliance. Interventionswere either standard fluoride toothpaste or CPP-ACP paste (Tooth Mousse™) in addition to thefluoride toothpaste. Participants received both interventions in a randomised order. Transversemicroradiography analysis was used to compare lesion mineral content profiles.Results:Mineral loss was reduced by 15.4 and 24.6% between the fluoride and CPP-ACP groups,respectively (p= 0.023). Lesion depth was reduced by 1.6 and 11.1% between the fluoride andCPP-ACP groups, respectively (p= 0.037). Lesion width was reduced by 4.5 and 15.3% betweenthe fluoride and CPP-ACP groups, respectively (p= 0.015).Conclusions:Remineralisation occurred regardless of treatment group allocation. However, theaddition of Tooth Mousse™resulted in a significantly increased remineralisation effect, comparedto fluoride alone. Tooth Mousse™may be beneficial for patients undergoing orthodontic treatmentwho are at high risk of demineralisation.