Synthesizing a nanoparticle distribution in magnetic fluid hyperthermia

• P. Di Barba ^[1] ; F. Dughiero ^[1] ; E. Sieni ^[1]
  1. [1] University of Padova
• Localización: Compel: International journal for computation and mathematics in electrical and electronic engineering, ISSN 0332-1649, Vol. 30, Nº 5 (Special Issue: HES 2010), 2011, págs. 1507-1516
• Idioma: inglés
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• Resumen

  • Purpose – The purpose of this paper is to present the synthesis of magnetic fluid characteristics, like diameter of nanoparticles (NPs) and their concentration, in order to obtain a prescribed temperature rate. An evolution strategy algorithm is used in the optimization procedure, while three‐dimensional finite‐element (FE) modelling is used for magnetic field and thermal field analysis in transient conditions.

    Design/methodology/approach – FE analysis has been used in order to compute the magnetic and thermal field in a suitable model of the tumor region. The power density due to NP has been accordingly derived.

    Findings – The NP distribution, giving a prescribed thermal response, is synthesized.

    Practical implications – The proposed method can be used to design a therapeutic treatment based on magnetic fluid hyperthermia.

    Originality/value – The paper belongs to a streamline of innovative studies on computational hyperthermia.