Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

• Susana V. ^[1] ; Paul ^[2] ; Shashank ^[3]
  1. [1] Central Research Institute of Ferrous Metallurgy I P Bardina

     Central Research Institute of Ferrous Metallurgy I P Bardina

     Rusia

     
  2. [2] Bunduc
  3. [3] Tripathi

  Mostrar afiliaciones +
• Localización: Science, ISSN 0036-8075, Vol. 356, Nº 6334, 2017, págs. 175-180
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV infection is unclear. Using convalescent plasma from DENV- and WNV-infected individuals, we found substantial enhancement of ZIKV infection in vitro that was mediated through immunoglobulin G engagement of Fcγ receptors. Administration of DENV- or WNV-convalescent plasma into ZIKV-susceptible mice resulted in increased morbidity—including fever, viremia, and viral loads in spinal cord and testes—and increased mortality. Antibody-dependent enhancement may explain the severe disease manifestations associated with recent ZIKV outbreaks and highlights the need to exert great caution when designing flavivirus vaccines.