The Microbiota of the Extremely Preterm Infant

• Autores: Mark A. Underwood, Kristin Sohn
• Localización: Clinics in Perinatology, ISSN 0095-5108, Vol. 44, Nº. 2, 2017, págs. 407-427
• Idioma: inglés
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• Resumen

  • Colonization of the extremely preterm infant’s gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra–high-risk cohort that is brand new from an evolutionary standpoint.