Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis
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Liengang Liu [1] ; Wei Bao [1]
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[1] Huazhong University of Science and Technology
Huazhong University of Science and Technology
China
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- Localización: American journal of epidemiology, ISSN-e 1476-6256, ISSN 0002-9262, Vol. 172, Nº. 6, 2010, págs. 631-636
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)n L (long) allele as compared with those with the (GT)n S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.
