Clinical effect of platelet rich fibrin in the treatment of periodontal intrabony defects. Systematic review and meta-analysis.

• Arbildo, Heber ^[5] ; Gamarra, Luis ^[6] ; Rojas, Sandra ^[1] ; Infantes, Edward ^[2] ; Lamas, Cesar ^[3] ; Vásquez, Hernán ^[4]
  1. [1] Universidad Nacional de Trujillo

     Universidad Nacional de Trujillo

     Provincia de Trujillo, Perú

     
  2. [2] Universidad Señor de Sipán

     Universidad Señor de Sipán

     Chiclayo, Perú

     
  3. [3] Universidad Católica Los Ángeles de Chimbote

     Universidad Católica Los Ángeles de Chimbote

     Chimbote, Perú

     
  4. [4] Universidad de San Martín de Porres

     Universidad de San Martín de Porres

     Perú

     
  5. [5] Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo. Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo. Centro de Salud Odontológico San Mateo. Trujillo.
  6. [6] Escuela de Estomatología, Universidad Privada Antonio Guillermo Urrelu. Cajamarca. Facultad de Estomatología, Universidad Nacional de Trujillo. Trujillo.

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• Localización: Journal of Oral Research, ISSN-e 0719-2479, ISSN 0719-2460, Vol. 6, Nº. 5, 2017, págs. 127-135
• Idioma: inglés
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• Resumen

  • Background: There is currently no gold standard biomaterial for the treatment of periodontal intrabony defects (PIDs). One of the current options is the use of platelet-rich fibrin (PRF). Objective: To determine the clinical effect of PRF in the treatment of PID through a systematic review and meta-analysis. Materials and Methods: A literature search was conducted up to February 2017 in the following biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS and in the Cochrane Central Register of Clinical Trials. The selection criteria included: randomized clinical trials published in the last 5 years, reporting clinical effects (probing depth, clinical insertion level or gingival recession), with a follow-up time equal to or greater than 6 months, and sample size larger than or equal to 10 patients reporting the use of PRF as a treatment for PID. The methodological quality of the studies was analyzed using the Cochrane Handbook of Systematic Reviews of Interventions as a reference. Results: The search strategy yielded 20 articles. A reduction in probing depth and an increase in clinical insertion level or a reduction in gingival recession is reported, when using PRF alone or in combination with another biomaterial or substance that stimulates tissue regeneration. Conclusion: The literature suggests that the use of PRF in the treatment of PIDs has a beneficial clinical effect when compared to control treatments.