Nucleophilic Aromatic Substitution—Addition and Identification of an Amine

• Steven W. Goldstein ^[1] ; Ashley Bill ^[1] ; Jyothi Dhuguru ^[2] ; Ola Ghoneim ^[2]
  1. [1] University of Saint Joseph

     University of Saint Joseph

     RAE de Macao (China)

     
  2. [2] University of Saint Joseph-School of Pharmacy, United States
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 94, Nº 9, 2017, págs. 1388-1390
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The addition of a nucleophilic functional group to an electron-deficient aromatic ring is a versatile reaction in the modern organic chemistry arsenal. The proper positioning of a leaving group on this ring effectively allows for a substitution reaction to occur. A 3 h laboratory experiment is described in which students utilize a common electrophilic aromatic ring and affect a substitution with an unknown amine, the identity of which is later characterized by the melting point and 1H NMR spectrum of the product.