Effects of maternal hydration status on the osmolality of maternal milk

María José Soto Méndez; A. Maldonado; Lauren Burgunder; Laura Scieszka; Ángel Gil Hernández; N.W. Solomons

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Effects of maternal hydration status on the osmolality of maternal milk

María José Soto-Méndez ^[2] ; Alejandra Maldonado ^[2] ; Lauren Burgunder ^[2] ; Laura Scieszka ^[2] ; Ángel Gil ^[1] ; Noel W. Solomons ^[2]
1. [1] Universidad de Granada
  
  Universidad de Granada
  
  Granada, España
2. [2] Centro de Estudios del Deterioro Sensorial, el Envejecimiento y el Metabolismo, Guatemala
Localización: Nutrición hospitalaria: Órgano oficial de la Sociedad Española de Nutrición Clínica y Metabolismo (SENPE), ISSN-e 1699-5198, ISSN 0212-1611, Vol. 33, Nº. Extra 3 (Suplemento 3), 2016 (Ejemplar dedicado a: II International and IV Spanish Hydration Congress. Toledo, December 2nd - 4th, 2015), págs. 60-66
Idioma: inglés
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Resumen
- Background: It has been demonstrated that human milk osmolality (Mosm) is regulated within an established range, typically 290 to 300 mOsm/kg, and appears to be resistant to effects of maternal dehydration, as refl ected by high urinary osmolality (Uosm).
  
  Objective: To determine the degree of association between Mosm and Uosm at a common point in time, as well as the reproducibility of both measures over a one-week interval of sampling.
  
  Methods: Mosm and Uosm were measured with a Vogel Löser 450 osmometer on samples of the respective biological fl uids collected concurrently in 31 lactating women, with infants aged between 30 and 340 days. In the fi rst 15 women recruited, collections were repeated 7 days after the initial ones.
  
  Results: The median Mosm for the 46 samples collected was 308 mOsm/kg with a range from 288 to 448 mOsm/kg. The corresponding values for Uosm were 598 mOsm/kg with a range from 93 to 1,678 mOsm/kg. The Spearman rank-order correlation coefficient for within-individual association of Mosm and Uosm was r = 0.214 (p = 0.153). The median Mosm for the 15 repeat-subjects was 309 mOsm/kg on both occasions, with a within-individual Spearman coeffi cient of r = 0.326 (p = 0.118). By contrast, for the Uosm, the within-subject association was much stronger, with r = 0.699 (p = 0.002).
  
  Conclusions: The osmometry technique proved to be a highly stable and reproducible measurement technique. Mosm and Uosm are not signifi cantly associated at a point in time. Intra-subject Mosm varies more across time than intra-subject Uosm.