Immune response of toddlers with history of prematurity
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S.P. Muraro [1] ; P.M. Pitrez [1] ; A.P.D. de Souza [1] ; B.N. Porto [1] ; J.E. Vargas [1] ; I.P. Ewald [1] ; J.P. Heinzmann-Filho [1] ; G. dos Santos [1] ; T.S. Baptista [1] ; T.D. Gandolfi [1] ; F.D. Machado [1] ; M.H. Jones [2] ; C. Bonorino
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[1] Pontifícia Universidade Católica do Rio Grande do Sul
Pontifícia Universidade Católica do Rio Grande do Sul
Brasil
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[2] Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, BrazilInstitute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 45, Nº. 5, 2017, págs. 425-431
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Background It is not quite well established how immune responses differ in term and preterm infants beyond the first year of life. This study aimed to evaluate aspects of the innate and adaptive immune responses in a group of preterm infants in comparison with their term peers.
Methods In this cross-sectional study peripheral blood mononuclear cells (PBMC) were isolated from preterm and term children at age three years. Innate immune response was evaluated by the analysis of TLR receptors expression on CD11c+HLADRhigh cells and inflammatory cytokine production after PBMC stimulation with Toll like receptors (TLR) ligands. Adaptive immune response was evaluated by T cells’ phenotyping and function after stimulation with polyclonal conventional T cell stimulus.
Conclusion We have found that the patterns of innate and adaptive immune responses at 3 years of age were not affected by the fact of the children having being born preterm or at term.
