Single nucleotide polymorphisms of IL-2, but not IL-12 and IFN-γ, are associated with increased susceptibility to chronic spontaneous urticaria

M. Movahedi; M. Tavakol; F. Rahmani; A.A. Amirzargar; A Z Bidoki; Kazem Heidari; M. Gharagozlou; A. Aghamohammadi; M. Nabavi; S. Soltani; Nima Rezaei

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Single nucleotide polymorphisms of IL-2, but not IL-12 and IFN-γ, are associated with increased susceptibility to chronic spontaneous urticaria

M. Movahedi ^[1] ; M. Tavakol ^[3] ; F. Rahmani ^[1] ; A.A. Amirzargar ^[1] ; A.Z. Bidoki ^[1] ; K. Heidari ^[1] ; M. Gharagozlou ^[1] ; A. Aghamohammadi ^[1] ; M. Nabavi ^[2] ; S. Soltani ^[1] ; N. Rezaei ^[1]
1. [1] Tehran University of Medical Sciences
  
  Tehran University of Medical Sciences
  
  Irán
2. [2] Iran University of Medical Sciences
  
  Iran University of Medical Sciences
  
  Irán
3. [3] Alborz University of Medical Sciences, Irán
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 45, Nº. 4, 2017, págs. 333-338
Idioma: inglés
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Resumen
- Background A clear picture of interaction of Th1/Th2 cytokines in pathogenesis of chronic spontaneous urticaria (CSU), remains elusive. Impaired IFN-γ production and decreased levels of IL-2 have been reported. The aim of this study was to evaluate the association of Th1 cytokines; IL-2, IL-12 and IFN-γ polymorphisms with CSU.
  
  Methods 90 patients with CSU and 140 age-sex matched subjects were included in this study. DNA samples were evaluated through PCR-SSP assay in order to detect single nucleotide polymorphisms of IL-12 (A/C −1188) or (rs3212227), IFN-γ (A/T UTR5644) or (rs2069717) and IL-2 (G/T −330 and G/T +166) or (rs2069762 and rs2069763).
  
  Results G allele at −330 at promoter region of IL-2 gene was overrepresented in CSU. Heterozygotes (GT) at this locus and heterozygotes at +166 of IL-2 gene (GT) were more prevalent in CSU group. Additionally, the haplotype GT for loci −330 and +166 of IL-2 gene was powerfully associated with CSU (OR (95%CI) = 57.29 (8.43–112.7)).
  
  Conclusions SNP at position −330 and +166 of IL-2 gene are differently expressed in CSU. The haplotype GT of IL-2 at −330 and +166 might confer vulnerability to a number of immunological disorders in Iranian region.