Senescence in health and disease
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Shenghui He [1] ; Norman E. Sharpless [1]
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[1] University of North Carolina
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- Localización: Cell, ISSN 0092-8674, Vol. 169, Nº. 6, 2017, págs. 1000-1011
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity, and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse consequences. These non-proliferating cells occupy key cellular niches and elaborate pro-inflammatory cytokines, contributing to aging-related diseases and morbidity. This model suggests that the abundance of senescent cells in vivo predicts “molecular,” as opposed to chronologic, age and that senescent cell clearance may mitigate aging-associated pathology.
