Relevance of in vitro 3-D skin models in dissecting cytokine contribution to psoriasis pathogenesis

• A. Chiricozzi ^[1] ; Marco Romanelli ; S. Panduri ^[1] ; E. Donetti ^[2] ; F. Prignano ^[3]
  1. [1] University of Pisa

     University of Pisa

     Pisa, Italia

     
  2. [2] University of Milan

     University of Milan

     Milán, Italia

     
  3. [3] Università di Firenze

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 32, Nº. 9, 2017, págs. 893-898
• Idioma: inglés
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• Resumen

  • Psoriasis is a chronic skin disease characterized by the activation of various T cell subsets secreting IFNγ, IL-17, and IL-22, dendritic cells producing TNFα and IFNα, and other immune cells including neutrophils and mast cells. Keratinocytes respond to different cytokine signals orchestrating innate and adaptive immune responses. In vitro studies sought to clarify the cytokine effects on keratinocytes in order to evaluate the centrality of these mediators in psoriasis pathogenesis. The aim of this review is to highlight the relevance of this peculiar in vitro approach in investigating cytokine effects on skin or multilayered epidermis. Particularly, we reported keynfindings supporting the cytokine role in psoriasis pathogenesis