Resumen de The blood in systemic disease
Haematological changes are common in systemic disease. Anaemia of chronic disease (ACD) occurs in inflammatory conditions where persistent cytokine release takes place. Autoimmune cytopenias may accompany systemic immune disorders, lymphomas and virus infections including human immunodeficiency virus (HIV) and Epstein–Barr virus (EBV). Autoimmune cytopenia and ACD may precede the diagnosis of the underlying disease. Liver disease causes coagulation defects through loss of clotting factors but also a procoagulant thrombotic state if protein C becomes deficient first. Neutrophilia occurs in acute bacterial infections; anaemias may be triggered by particular infections.
